Publications
The group’s main research focuses on understanding and targeting gene networks that control macrophage biology in metabolic disease, ageing and chronic kidney disease.
This system-level approach to target macrophage activation is expected to achieve timely and impactful translation and acceleration towards drug discovery.
All
2025
Grape Seed Proanthocyanidins: A Potential Microbiome-Targeted Intervention for Healthy Aging in Rats.
Molecular nutrition & food research
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18 Jun 2025
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pubmed:40534245
The spatial and temporal activation of macrophages during fibrosis.
Nature reviews. Immunology
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04 Jun 2025
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pubmed:40467841
2024
Fatty acid synthesis promotes inflammasome activation through NLRP3 palmitoylation.
Cell reports
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17 Jul 2024
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pubmed:39024103
Multi-tissue profiling of oxylipins reveal a conserved up-regulation of epoxide:diol ratio that associates with white adipose tissue inflammation and liver steatosis in obesity.
EBioMedicine
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26 Apr 2024
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pubmed:38677183
Comparative Analysis of Single-Cell RNA Sequencing Methods with and without Sample Multiplexing.
International journal of molecular sciences
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29 Mar 2024
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pubmed:38612639
WWP2 Regulates Renal Fibrosis and the Metabolic Reprogramming of Profibrotic Myofibroblasts.
Journal of the American Society of Nephrology : JASN
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19 Mar 2024
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pubmed:38502123
2023
Systems level identification of a matrisome-associated macrophage polarisation state in multi-organ fibrosis.
eLife
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14 Sep 2023
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pubmed:37706477
Multinucleation resets human macrophages for specialized functions at the expense of their identity.
EMBO reports
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05 Apr 2023
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pubmed:37016941
Multinucleation resets human macrophages for specialized functions at the expense of their identity.
EMBO reports
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04 Jan 2023
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pubmed:36597777
2022
The E3 ubiquitin ligase WWP2 regulates pro-fibrogenic monocyte infiltration and activity in heart fibrosis.
Nature communications
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30 Nov 2022
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pubmed:36450710
Immunolipidomics Reveals a Globoside Network During the Resolution of Pro-Inflammatory Response in Human Macrophages.
Frontiers in immunology
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30 Jun 2022
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pubmed:35844525
Glomerulonephritis and autoimmune vasculitis are independent of P2RX7 but may depend on alternative inflammasome pathways.
The Journal of pathology
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02 May 2022
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pubmed:35239186
2021
Adipoclast: a multinucleated fat-eating macrophage.
BMC biology
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19 Nov 2021
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pubmed:34794433
Sphingolipid metabolism during Toll-like receptor 4 (TLR4)-mediated macrophage activation.
British journal of pharmacology
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02 Sep 2021
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pubmed:34363204
Cardiac glycosides cause cytotoxicity in human macrophages and ameliorate white adipose tissue homeostasis.
British journal of pharmacology
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03 May 2021
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pubmed:33665823
Type I interferons affect the metabolic fitness of CD8
Nature communications
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31 Mar 2021
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pubmed:33790300
Longitudinal proteomic profiling of dialysis patients with COVID-19 reveals markers of severity and predictors of death.
eLife
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11 Mar 2021
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pubmed:33704068
Similarities and interplay between senescent cells and macrophages.
The Journal of cell biology
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01 Feb 2021
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pubmed:33355620
The versatile biochemistry of iron in macrophage effector functions.
The FEBS journal
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12 Jan 2021
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pubmed:33354925
2020
BCAT1 affects mitochondrial metabolism independently of leucine transamination in activated human macrophages.
Journal of cell science
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27 Nov 2020
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pubmed:33148611
A trans-eQTL network regulates osteoclast multinucleation and bone mass.
eLife
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19 Jun 2020
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pubmed:32553114
2019
Cardiac glycosides are broad-spectrum senolytics.
Nature metabolism
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21 Oct 2019
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pubmed:31799499
Acute Iron Deprivation Reprograms Human Macrophage Metabolism and Reduces Inflammation In Vivo.
Cell reports
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09 Jul 2019
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pubmed:31291584
Systems genetics identifies a macrophage cholesterol network associated with physiological wound healing.
JCI insight
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24 Jan 2019
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pubmed:30674726
2018
A systems-level framework for drug discovery identifies Csf1R as an anti-epileptic drug target.
Nature communications
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03 Sep 2018
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pubmed:30177815
Common signalling pathways in macrophage and osteoclast multinucleation.
Journal of cell science
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05 Jun 2018
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pubmed:29871956
Response to: 'M-CSF and GM-CSF monocyte-derived macrophages in systemic sclerosis: the two sides of the same coin?' by Lescoat
Annals of the rheumatic diseases
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09 Mar 2018
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pubmed:29523522
Epoxygenase inactivation exacerbates diet and aging-associated metabolic dysfunction resulting from impaired adipogenesis.
Molecular metabolism
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09 Mar 2018
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pubmed:29656108
Changes in macrophage transcriptome associate with systemic sclerosis and mediate
Annals of the rheumatic diseases
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17 Jan 2018
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pubmed:29348297
2017
BCAT1 controls metabolic reprogramming in activated human macrophages and is associated with inflammatory diseases.
Nature communications
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12 Jul 2017
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pubmed:28699638
Identification of Ceruloplasmin as a Gene that Affects Susceptibility to Glomerulonephritis Through Macrophage Function.
Genetics
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26 Apr 2017
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pubmed:28450461
Genome-wide analysis of differential RNA editing in epilepsy.
Genome research
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01 Mar 2017
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pubmed:28250018
A Bayesian Approach for Analysis of Whole-Genome Bisulfite Sequencing Data Identifies Disease-Associated Changes in DNA Methylation.
Genetics
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17 Feb 2017
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pubmed:28213474
Systems Genetics as a Tool to Identify Master Genetic Regulators in Complex Disease.
Methods in molecular biology (Clifton, N.J.)
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01 Jan 2017
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pubmed:27933533
2016
Identification of a nutrient-sensing transcriptional network in monocytes by using inbred rat models on a cafeteria diet.
Disease models & mechanisms
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13 Jul 2016
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pubmed:27483348
Human Chorionic Stem Cells: Podocyte Differentiation and Potential for the Treatment of Alport Syndrome.
Stem cells and development
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18 Feb 2016
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pubmed:26728561
2015
Leptin signal transduction underlies the differential metabolic response of LEW and WKY rats to cafeteria diet.
Journal of molecular endocrinology
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08 Oct 2015
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pubmed:26450996
Use of Quantitative Real Time Polymerase Chain Reaction to Assess Gene Transcripts Associated With Antibody-Mediated Rejection of Kidney Transplants.
Transplantation
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01 Sep 2015
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pubmed:25675206
Macrophage epoxygenase determines a profibrotic transcriptome signature.
Journal of immunology (Baltimore, Md. : 1950)
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03 Apr 2015
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pubmed:25840911
Systems genetics identifies Sestrin 3 as a regulator of a proconvulsant gene network in human epileptic hippocampus.
Nature communications
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23 Jan 2015
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pubmed:25615886
2014
Integrating phosphoproteome and transcriptome reveals new determinants of macrophage multinucleation.
Molecular & cellular proteomics : MCP
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22 Dec 2014
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pubmed:25532521
Unique regulatory properties of mesangial cells are genetically determined in the rat.
PloS one
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24 Oct 2014
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pubmed:25343449
Kcnn4 is a regulator of macrophage multinucleation in bone homeostasis and inflammatory disease.
Cell reports
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14 Aug 2014
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pubmed:25131209
2013
JunD/AP1 regulatory network analysis during macrophage activation in a rat model of crescentic glomerulonephritis.
BMC systems biology
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22 Sep 2013
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pubmed:24053712
Experimental crescentic glomerulonephritis: a new bicongenic rat model.
Disease models & mechanisms
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15 Aug 2013
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pubmed:24046355
Potassium channel openers increase aortic elastic fiber formation and reverse the genetically determined elastin deficit in the BN rat.
Hypertension (Dallas, Tex. : 1979)
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05 Aug 2013
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pubmed:23918751
Combined ChIP-Seq and transcriptome analysis identifies AP-1/JunD as a primary regulator of oxidative stress and IL-1β synthesis in macrophages.
BMC genomics
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11 Feb 2013
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pubmed:23398888
2012
P2X7 receptor-mediated Nlrp3-inflammasome activation is a genetic determinant of macrophage-dependent crescentic glomerulonephritis.
Journal of leukocyte biology
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22 Oct 2012
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pubmed:23089744
Genetic susceptibility to experimental autoimmune glomerulonephritis in the Wistar Kyoto rat.
The American journal of pathology
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22 Mar 2012
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pubmed:22445570
2011
Role of novel rat-specific Fc receptor in macrophage activation associated with crescentic glomerulonephritis.
The Journal of biological chemistry
·
19 Dec 2011
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pubmed:22184119
AP-1 transcription factor JunD confers protection from accelerated nephrotoxic nephritis and control podocyte-specific Vegfa expression.
The American journal of pathology
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03 May 2011
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pubmed:21640331
2010
Characterization of the macrophage transcriptome in glomerulonephritis-susceptible and -resistant rat strains.
Genes and immunity
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23 Dec 2010
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pubmed:21179115
Genetic loci modulate macrophage activity and glomerular damage in experimental glomerulonephritis.
Journal of the American Society of Nephrology : JASN
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20 May 2010
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pubmed:20488952
The genome sequence of the spontaneously hypertensive rat: Analysis and functional significance.
Genome research
·
29 Apr 2010
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pubmed:20430781
Genetic mapping and positional cloning.
Methods in molecular biology (Clifton, N.J.)
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01 Jan 2010
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pubmed:20013223
2009
Kallikreins: unravelling the genetics of autoimmune glomerulonephritis.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
·
07 Aug 2009
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pubmed:19666659
2008
Differential expression of lysyl oxidases LOXL1 and LOX during growth and aging suggests specific roles in elastin and collagen fiber remodeling in rat aorta.
Rejuvenation research
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01 Oct 2008
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pubmed:18803461
Jund is a determinant of macrophage activation and is associated with glomerulonephritis susceptibility.
Nature genetics
·
01 May 2008
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pubmed:18443593
2007
Genes expressed by both mesangial cells and bone marrow-derived cells underlie genetic susceptibility to crescentic glomerulonephritis in the rat.
Journal of the American Society of Nephrology : JASN
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02 May 2007
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pubmed:17475818
Quantitative genetic basis of arterial phenotypes in the Brown Norway rat.
Physiological genomics
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13 Mar 2007
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pubmed:17356016
2005
Chromosomal mapping of quantitative trait loci controlling elastin content in rat aorta.
Hypertension (Dallas, Tex. : 1979)
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24 Jan 2005
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pubmed:15668357
2004
Characteristics of the aortic elastic network and related phenotypes in seven inbred rat strains.
American journal of physiology. Heart and circulatory physiology
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07 Oct 2004
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pubmed:15471977