Publications
The group’s main research focuses on understanding and targeting gene networks that control macrophage biology in metabolic disease, ageing and chronic kidney disease.
This system-level approach to target macrophage activation is expected to achieve timely and impactful translation and acceleration towards drug discovery.
All
2025
The spatial and temporal activation of macrophages during fibrosis.
Nature reviews. Immunology
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04 Jun 2025
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pubmed:40467841
2024
Fatty acid synthesis promotes inflammasome activation through NLRP3 palmitoylation.
Cell reports
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17 Jul 2024
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pubmed:39024103
Multi-tissue profiling of oxylipins reveal a conserved up-regulation of epoxide:diol ratio that associates with white adipose tissue inflammation and liver steatosis in obesity.
EBioMedicine
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26 Apr 2024
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pubmed:38677183
Comparative Analysis of Single-Cell RNA Sequencing Methods with and without Sample Multiplexing.
International journal of molecular sciences
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29 Mar 2024
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pubmed:38612639
WWP2 Regulates Renal Fibrosis and the Metabolic Reprogramming of Profibrotic Myofibroblasts.
Journal of the American Society of Nephrology : JASN
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19 Mar 2024
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pubmed:38502123
2023
Systems level identification of a matrisome-associated macrophage polarisation state in multi-organ fibrosis.
eLife
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14 Sep 2023
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pubmed:37706477
Multinucleation resets human macrophages for specialized functions at the expense of their identity.
EMBO reports
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05 Apr 2023
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pubmed:37016941
Multinucleation resets human macrophages for specialized functions at the expense of their identity.
EMBO reports
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04 Jan 2023
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pubmed:36597777
2022
The E3 ubiquitin ligase WWP2 regulates pro-fibrogenic monocyte infiltration and activity in heart fibrosis.
Nature communications
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30 Nov 2022
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pubmed:36450710
Immunolipidomics Reveals a Globoside Network During the Resolution of Pro-Inflammatory Response in Human Macrophages.
Frontiers in immunology
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30 Jun 2022
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pubmed:35844525
Glomerulonephritis and autoimmune vasculitis are independent of P2RX7 but may depend on alternative inflammasome pathways.
The Journal of pathology
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02 May 2022
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pubmed:35239186
2021
Adipoclast: a multinucleated fat-eating macrophage.
BMC biology
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19 Nov 2021
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pubmed:34794433
Sphingolipid metabolism during Toll-like receptor 4 (TLR4)-mediated macrophage activation.
British journal of pharmacology
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02 Sep 2021
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pubmed:34363204
Cardiac glycosides cause cytotoxicity in human macrophages and ameliorate white adipose tissue homeostasis.
British journal of pharmacology
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03 May 2021
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pubmed:33665823
Type I interferons affect the metabolic fitness of CD8
Nature communications
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31 Mar 2021
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pubmed:33790300
Longitudinal proteomic profiling of dialysis patients with COVID-19 reveals markers of severity and predictors of death.
eLife
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11 Mar 2021
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pubmed:33704068
Similarities and interplay between senescent cells and macrophages.
The Journal of cell biology
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01 Feb 2021
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pubmed:33355620
The versatile biochemistry of iron in macrophage effector functions.
The FEBS journal
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12 Jan 2021
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pubmed:33354925
2020
BCAT1 affects mitochondrial metabolism independently of leucine transamination in activated human macrophages.
Journal of cell science
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27 Nov 2020
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pubmed:33148611
A trans-eQTL network regulates osteoclast multinucleation and bone mass.
eLife
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19 Jun 2020
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pubmed:32553114
2019
Cardiac glycosides are broad-spectrum senolytics.
Nature metabolism
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21 Oct 2019
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pubmed:31799499
Acute Iron Deprivation Reprograms Human Macrophage Metabolism and Reduces Inflammation In Vivo.
Cell reports
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09 Jul 2019
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pubmed:31291584
Systems genetics identifies a macrophage cholesterol network associated with physiological wound healing.
JCI insight
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24 Jan 2019
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pubmed:30674726
2018
A systems-level framework for drug discovery identifies Csf1R as an anti-epileptic drug target.
Nature communications
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03 Sep 2018
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pubmed:30177815
Common signalling pathways in macrophage and osteoclast multinucleation.
Journal of cell science
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05 Jun 2018
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pubmed:29871956
Response to: 'M-CSF and GM-CSF monocyte-derived macrophages in systemic sclerosis: the two sides of the same coin?' by Lescoat
Annals of the rheumatic diseases
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09 Mar 2018
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pubmed:29523522
Epoxygenase inactivation exacerbates diet and aging-associated metabolic dysfunction resulting from impaired adipogenesis.
Molecular metabolism
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09 Mar 2018
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pubmed:29656108
Changes in macrophage transcriptome associate with systemic sclerosis and mediate
Annals of the rheumatic diseases
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17 Jan 2018
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pubmed:29348297
2017
BCAT1 controls metabolic reprogramming in activated human macrophages and is associated with inflammatory diseases.
Nature communications
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12 Jul 2017
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pubmed:28699638
Identification of Ceruloplasmin as a Gene that Affects Susceptibility to Glomerulonephritis Through Macrophage Function.
Genetics
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26 Apr 2017
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pubmed:28450461
Genome-wide analysis of differential RNA editing in epilepsy.
Genome research
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01 Mar 2017
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pubmed:28250018
A Bayesian Approach for Analysis of Whole-Genome Bisulfite Sequencing Data Identifies Disease-Associated Changes in DNA Methylation.
Genetics
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17 Feb 2017
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pubmed:28213474
Systems Genetics as a Tool to Identify Master Genetic Regulators in Complex Disease.
Methods in molecular biology (Clifton, N.J.)
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01 Jan 2017
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pubmed:27933533
2016
Identification of a nutrient-sensing transcriptional network in monocytes by using inbred rat models on a cafeteria diet.
Disease models & mechanisms
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13 Jul 2016
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pubmed:27483348
Human Chorionic Stem Cells: Podocyte Differentiation and Potential for the Treatment of Alport Syndrome.
Stem cells and development
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18 Feb 2016
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pubmed:26728561
2015
Leptin signal transduction underlies the differential metabolic response of LEW and WKY rats to cafeteria diet.
Journal of molecular endocrinology
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08 Oct 2015
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pubmed:26450996
Use of Quantitative Real Time Polymerase Chain Reaction to Assess Gene Transcripts Associated With Antibody-Mediated Rejection of Kidney Transplants.
Transplantation
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01 Sep 2015
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pubmed:25675206
Macrophage epoxygenase determines a profibrotic transcriptome signature.
Journal of immunology (Baltimore, Md. : 1950)
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03 Apr 2015
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pubmed:25840911
Systems genetics identifies Sestrin 3 as a regulator of a proconvulsant gene network in human epileptic hippocampus.
Nature communications
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23 Jan 2015
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pubmed:25615886
2014
Integrating phosphoproteome and transcriptome reveals new determinants of macrophage multinucleation.
Molecular & cellular proteomics : MCP
·
22 Dec 2014
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pubmed:25532521
Unique regulatory properties of mesangial cells are genetically determined in the rat.
PloS one
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24 Oct 2014
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pubmed:25343449
Kcnn4 is a regulator of macrophage multinucleation in bone homeostasis and inflammatory disease.
Cell reports
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14 Aug 2014
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pubmed:25131209
2013
JunD/AP1 regulatory network analysis during macrophage activation in a rat model of crescentic glomerulonephritis.
BMC systems biology
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22 Sep 2013
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pubmed:24053712
Experimental crescentic glomerulonephritis: a new bicongenic rat model.
Disease models & mechanisms
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15 Aug 2013
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pubmed:24046355
Potassium channel openers increase aortic elastic fiber formation and reverse the genetically determined elastin deficit in the BN rat.
Hypertension (Dallas, Tex. : 1979)
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05 Aug 2013
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pubmed:23918751
Combined ChIP-Seq and transcriptome analysis identifies AP-1/JunD as a primary regulator of oxidative stress and IL-1β synthesis in macrophages.
BMC genomics
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11 Feb 2013
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pubmed:23398888
2012
P2X7 receptor-mediated Nlrp3-inflammasome activation is a genetic determinant of macrophage-dependent crescentic glomerulonephritis.
Journal of leukocyte biology
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22 Oct 2012
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pubmed:23089744
Genetic susceptibility to experimental autoimmune glomerulonephritis in the Wistar Kyoto rat.
The American journal of pathology
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22 Mar 2012
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pubmed:22445570
2011
Role of novel rat-specific Fc receptor in macrophage activation associated with crescentic glomerulonephritis.
The Journal of biological chemistry
·
19 Dec 2011
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pubmed:22184119
AP-1 transcription factor JunD confers protection from accelerated nephrotoxic nephritis and control podocyte-specific Vegfa expression.
The American journal of pathology
·
03 May 2011
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pubmed:21640331
2010
Characterization of the macrophage transcriptome in glomerulonephritis-susceptible and -resistant rat strains.
Genes and immunity
·
23 Dec 2010
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pubmed:21179115
Genetic loci modulate macrophage activity and glomerular damage in experimental glomerulonephritis.
Journal of the American Society of Nephrology : JASN
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20 May 2010
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pubmed:20488952
The genome sequence of the spontaneously hypertensive rat: Analysis and functional significance.
Genome research
·
29 Apr 2010
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pubmed:20430781
Genetic mapping and positional cloning.
Methods in molecular biology (Clifton, N.J.)
·
01 Jan 2010
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pubmed:20013223
2009
Kallikreins: unravelling the genetics of autoimmune glomerulonephritis.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
·
07 Aug 2009
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pubmed:19666659
2008
Differential expression of lysyl oxidases LOXL1 and LOX during growth and aging suggests specific roles in elastin and collagen fiber remodeling in rat aorta.
Rejuvenation research
·
01 Oct 2008
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pubmed:18803461
Jund is a determinant of macrophage activation and is associated with glomerulonephritis susceptibility.
Nature genetics
·
01 May 2008
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pubmed:18443593
2007
Genes expressed by both mesangial cells and bone marrow-derived cells underlie genetic susceptibility to crescentic glomerulonephritis in the rat.
Journal of the American Society of Nephrology : JASN
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02 May 2007
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pubmed:17475818
Quantitative genetic basis of arterial phenotypes in the Brown Norway rat.
Physiological genomics
·
13 Mar 2007
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pubmed:17356016
2005
Chromosomal mapping of quantitative trait loci controlling elastin content in rat aorta.
Hypertension (Dallas, Tex. : 1979)
·
24 Jan 2005
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pubmed:15668357
2004
Characteristics of the aortic elastic network and related phenotypes in seven inbred rat strains.
American journal of physiology. Heart and circulatory physiology
·
07 Oct 2004
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pubmed:15471977